tert-Butyl 4-(chloromethyl)-1-piperidinecarboxylate
tert-Butyl 4-(chloromethyl)tetrahydro-1(2H)-pyridinecarboxylate
CAS: 479057-79-9
Molecular Formula: C11H20ClNO2
tert-Butyl 4-(chloromethyl)-1-piperidinecarboxylate - Names and Identifiers
tert-Butyl 4-(chloromethyl)-1-piperidinecarboxylate - Physico-chemical Properties
| Molecular Formula | C11H20ClNO2 |
| Molar Mass | 233.74 |
| Density | 1.076 |
| Melting Point | 49～51℃ |
| Boling Point | 303.2±15.0 °C(Predicted) |
| pKa | -1.82±0.40(Predicted) |
| Storage Condition | 2-8°C |
| Sensitive | Irritant |
| MDL | MFCD08689676 |
tert-Butyl 4-(chloromethyl)-1-piperidinecarboxylate - Introduction
tert-Butyl 4-(chloromethyl)tetrahydro-1(2H)-pyridinecarboxylate is an organic compound with the chemical formula C11H18ClNO2. The following is an introduction to its nature, use, formulation and safety information:
Nature:
-Appearance: colorless liquid
-Molecular weight: 227.72g/mol
-Melting point:-75°C
-Boiling Point: 195-198°C
-Density: about 1.07 g/mL
-Solubility: Soluble in organic solvents such as ether and acetone
Use:
tert-Butyl 4-(chloromethyl)tetrahydro-1(2H)-pyridinecarboxylate are commonly used as intermediates in organic synthesis. It can be used in the preparation of various organic compounds, such as pesticides and pharmaceuticals, etc.
Preparation Method:
tert-Butyl 4-(chloromethyl)tetrahydro-1(2H)-pyridinecarboxylate are generally prepared by the following steps:
1. First, tert-butyl alcohol is reacted with anhydrous hydrochloric acid to obtain tert-butyl ammonium chloride.
2. The obtained tert-butylammonium chloride is then reacted with piperidine to generate 4-(chloromethyl) piperidine.
3. Finally, the generated 4-(chloromethyl) piperidine is reacted with tert-butyl formate to obtain the final product.
Safety Information:
tert-Butyl 4-(chloromethyl)tetrahydro-1(2H)-pyridinecarboxylate is relatively safe under normal conditions of use, but the following safety measures still need to be observed:
-Use appropriate protective measures during operation, such as wearing chemical protective gloves and goggles.
-Avoid contact with skin, eyes and mucous membranes. In case of contact, rinse immediately with plenty of water.
-Avoid inhaling its vapor and operate in a well-ventilated place.
-Do not mix it with strong oxidants or strong acids to avoid dangerous reactions.
-Storage should be sealed and kept away from open flames and high temperatures.
Please note that the above information is for reference only. When using or handling chemicals, it is important to follow the appropriate safety procedures and laboratory practices.
Nature:
-Appearance: colorless liquid
-Molecular weight: 227.72g/mol
-Melting point:-75°C
-Boiling Point: 195-198°C
-Density: about 1.07 g/mL
-Solubility: Soluble in organic solvents such as ether and acetone
Use:
tert-Butyl 4-(chloromethyl)tetrahydro-1(2H)-pyridinecarboxylate are commonly used as intermediates in organic synthesis. It can be used in the preparation of various organic compounds, such as pesticides and pharmaceuticals, etc.
Preparation Method:
tert-Butyl 4-(chloromethyl)tetrahydro-1(2H)-pyridinecarboxylate are generally prepared by the following steps:
1. First, tert-butyl alcohol is reacted with anhydrous hydrochloric acid to obtain tert-butyl ammonium chloride.
2. The obtained tert-butylammonium chloride is then reacted with piperidine to generate 4-(chloromethyl) piperidine.
3. Finally, the generated 4-(chloromethyl) piperidine is reacted with tert-butyl formate to obtain the final product.
Safety Information:
tert-Butyl 4-(chloromethyl)tetrahydro-1(2H)-pyridinecarboxylate is relatively safe under normal conditions of use, but the following safety measures still need to be observed:
-Use appropriate protective measures during operation, such as wearing chemical protective gloves and goggles.
-Avoid contact with skin, eyes and mucous membranes. In case of contact, rinse immediately with plenty of water.
-Avoid inhaling its vapor and operate in a well-ventilated place.
-Do not mix it with strong oxidants or strong acids to avoid dangerous reactions.
-Storage should be sealed and kept away from open flames and high temperatures.
Please note that the above information is for reference only. When using or handling chemicals, it is important to follow the appropriate safety procedures and laboratory practices.
Last Update：2024-04-09 15:18:10
